New Treatment Brings Hope for Odor Associated with Nagashima-type Palmoplantar Keratosis

A new study published in the Journal of Investigative Dermatology offers hope for people with Nagashima-type palmoplantar keratosis who experience a distinctive foot odor that can significantly impact their quality of life.

Nagashima-type palmoplantar keratosis, sometimes referred to as SERPINB7-related palmoplantar epidermal differentiation disorder, is the most common form of palmoplantar keratoderma in East Asia. According to researchers, the condition is characterized by reddened, thickened skin on the palms and soles (hyperkeratosis), excessive sweating in these areas, and a distinctive foot odor.

The research team set out to understand the underlying causes of this odor by investigating the microbiome—the community of microorganisms—on the soles of the feet. Their findings revealed that compared to healthy controls, individuals with this condition showed significantly higher objective odor scores and an increased bacterial load, particularly between the toes.

Microbial Imbalance Identified

Perhaps most notably, the researchers discovered that people with this form of keratosis had reduced microbial diversity on their feet compared to those without the condition. This imbalance in the normal microbiome, known as dysbiosis, appears to play a crucial role in the development of the distinctive odor.

The study also evaluated the effectiveness of topical benzoyl peroxide—a treatment commonly used for acne—in addressing this condition. While the brief excerpt doesn't detail the complete results, the title suggests promising improvements with this treatment approach.

This research represents an important step forward in understanding and potentially treating one of the more socially challenging aspects of this genetic skin condition. By addressing the microbial imbalance, medical professionals may be able to significantly improve quality of life for those affected by this form of keratosis.